Creatinine Enzymatic (C7548-120)
For the quantitative enzymatic determination of creatinine in serum and urine. For In Vitro Diagnostic Use Only.
Creatinine is a catabolic product of creatine, which is used in skeletal muscle contraction. The daily production of creatine, and subsequently creatinine, depends on muscle mass, which fluctuates very little. Creatinine is excreted entirely by the kidneys and therefore is directly proportional to renal excretory function. Thus with normal renal excretory function, the serum creatinine level should remain constant and normal. Only renal disorders, such as glomerulonephritis, pyelonephritis, acute tubular necrosis, and urinary obstruction, will cause an abnormal elevation in creatinine. The Pointe Scientific, Inc. method employs a two reagent system which eliminates interference by endogenous creatine and ascorbic acid.